Detroit Lions vs Los Angeles Chargers Betting Odds, AI Picks and Analysis

The Detroit Lions are set to visit the Los Angeles Chargers on Sunday afternoon for a big game in the National Football League (NFL). The Lions vs. Chargers odds are now set ahead of this matchup, and it’s the perfect time to start putting together some wagers.
Detroit is coming into this game with an overall record of 6-2, and they are currently on top of the NFC North standings. The Los Angeles Chargers have rallied to get back to the .500 mark at 4-4, and now this team is trying to keep the momentum going by picking up a big upset on Sunday. This is one of the main reasons for following the Lions vs Chargers odds.
Game Information
DETROIT LIONS vs LOS ANGELES CHARGERS |
Location of the Game: SoFi Stadium, Los Angeles, California |
Date and Time: Sunday, November 12, 4:05 PM ET |
Reason: NFL Week 10 Regular Season Game |
How to watch: CBS |

AI Predictions and SportBettingAI Picks
Following this, we present the AI Predictions and SportBettingAI Picks for this Lions vs Chargers odds game:
TEAM | RECORD | AI PICKS | SportBettingAI PICKS | |||
LIONS | 6-2 | 27 | 50 |
SPREAD DET -3.0 |
MONEYLINE DET -155 |
TOTAL OVER 48.5 |
CHARGERS | 4-4 | 23 |
Lions vs Chargers Odds
Here is a closer look at the Lions vs Chargers odds for this game:
Detroit Lions Game Analysis

The Detroit Lions standings are in a great position after nine weeks as they are currently on top of the NFC North at 6-2. Detroit is a team that has been scoring a ton of points on offense, and a majority of that damage has come through the air.
The NFL odds for this team are typically dictated on how well Jared Goff performs on offense, and he is having a monster season for this team. Goff has thrown for 2,174 yards this season, and he is always looking for Amon-Ra St. Brown when this team has the football.
The NFL injuries have started to hurt this team a bit though as running back David Montgomery is currently out of the lineup. Montgomery leads this team with six rushing touchdowns through the first nine weeks.
Detroit is a team that sometimes forgets about playing defense, and that can create some issues in this matchup. The Lions will have to be great on both sides of the football in order to win this game.
Los Angeles Chargers Game Analysis

This Los Angeles Chargers roster has dealt with injuries all season long, but they are finally starting to get their best players on the field. The result has been back-to-back big wins, but they are now facing a much tougher opponent in this game.
Quarterback Justin Herbert is having another huge season for this team as he has thrown for 2,026 yards and 13 touchdowns this season. Austin Ekeler is now a major part of the offense again, and that’s not something that opponents want to see.
The Chargers are not one of the best NFL teams when it comes to defense, but that unit has been sharp as well of late. If Los Angeles is going to continue to climb up the NFL standings then they will need both sides of the football to shine.
Detroit Lions vs Los Angeles Chargers Head-to-Head
You don’t often get to make NFL picks on a matchup between the Detroit Lions and Los Angeles Chargers as they are in different conferences. But for the Lions vs Chargers odds, there have been just 12 total meetings between the two teams and Los Angeles has won seven of those 12 games.
For this Lions vs Chargers odds, actually the first matchup since 2019, and Detroit was a winner in that game. Since both teams are much different now than they were back then, you won’t get much help from looking back at that game.
The Lions vs Chargers odds on Sunday afternoon are tight and that should set the stage for a terrific battle in Los Angeles. There are some other great Week 10 games on the schedule, but this is one that you simply don’t want to miss out on.