Penn State Nittany Lions vs Ohio State Buckeyes Odds, AI Picks, and AI Prediction

The Penn State vs Ohio State odds are going to be some of the most important of the weekend, as this is a monster game in the Big Ten Conference. With the first release of the CFP rankings coming up soon, each team will need to come up with a win in this matchup.
This has been a rivalry controlled by Ohio State in recent years, but there doesn’t appear to be much separation this time around. These two teams still have to deal with Michigan, but the winning team is going to be able to keep pace.
Penn State vs Ohio State Odds
TEAM | POINT SPREAD | MONEYLINE | OVER/UNDER |
PENN STATE | +4.5 | +163 | O 45.5 |
OHIO STATE | -4.5 | -190 | U 45.5 |
The Penn State vs Ohio State odds on Saturday show the Buckeyes being a slight betting favorite at -4.5 over the Nittany Lions. You can also bet on the over/under, and that is another popular betting option for any game.
The 2023 college football regular season has been filled with upsets, and that is what Penn State will be trying to pull off in this one. You can bet on the Nittany Lions to keep it within four points to cover the spread or bet on them at +200 on the moneyline.
Game Information
PENN STATE NITTANY LIONS vs. OHIO STATE BUCKEYES |
Location of the Game: Ohio Stadium, Columbus, OH |
Date and Time: Saturday, October 21, 12:00 PM ET |
Reason: (Why are they playing? If they are in the regular season, playoff, or finals) |
How to watch: FOX |
Betting Preview
Penn State Playing Some Defense

Penn State is one of the best defensive teams in the country this season, as they are allowing just 191 yards per game this season. The Nittany Lions have been especially strong against the run, as they are holding opponents to just 73 yards per game.
While most people recognize that the defense is leading the charge for Penn State, the offense has been playing well also. The Nittany Lions are averaging 426 yards per game this season, and the offense spends a ton of time on the field.
The Nittany Lions are facing a team that wants to throw the football, but this team is going to be looking to run. Penn State has racked up more than 200 rushing yards per game, and that will be a big key to success this season.
Quarterback Drew Allar has thrown for 1,254 yards and 12 touchdowns this season, and taking care of the football is going to be a key for the youngster.
Buckeyes Lighting Up the Scoreboard

If you have done some Ohio State betting this season, then you probably know that this team has been scoring points like crazy. Ohio State is averaging 443 yards per game this season, and they are always on the attack when they have the football.
Quarterback Kyle McCord still has some work to do before he becomes a superstar in college, but he has thrown for 11 touchdowns and one interception this season. McCord will be looking to get the ball to Marvin Harrison Jr., as he is the best player in the country.
Marvin Harrison Jr. has 31 catches for 604 yards this season, and he is going to attract a ton of attention in this game. Ohio State is easily the best offensive team in this game, but that defense will need to show up as well.
AI Betting Picks
ODDS | AI BETTING PICKS |
OVER/UNDER | UNDER 45.5 |
SPREAD | Penn State Nittany Lions +4.5 |
After taking a close look at the Penn State vs Ohio State Odds, you should come to the conclusion that this is going to be a great game. The Penn State odds to win this game are pretty good, and they have a defense that can get that job done.
This Nittany Lions vs Buckeyes is going to be a real battle for the entire game, and you simply can’t pass up on taking the points. Get Penn State at +4.5 in this matchup and also take the under 45.5 points.
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